000013139 001__ 13139
000013139 005__ 20190607170157.020190607170157.0
000013139 022__ $$a2277-4572$$a2277-4572
000013139 041__ $$afre$$afre
000013139 100__ $$aAHUI, Marie Laure Berthe$$aAHUI, Marie Laure Berthe
000013139 245__ $$aGinger with honey prevents Th2-mediated immune responses in a mouse model of airway inflammation$$aGinger with honey prevents Th2-mediated immune responses in a mouse model of airway inflammation
000013139 260__ $$c2013$$c2013
000013139 300__ $$a66-69$$a66-69
000013139 310__ $$a2(1)$$a2(1)
000013139 520__ $$aIn traditional medicine people use the association of ginger and honey to treat some respiratory disorder. The aim of the present study was to examine the effects of the association of ginger and honey on respiratory disorder in mice. Here we showed that ginger-honey can exert such functions in vivo, namely in a mouse model of Th2-mediated pulmonary inflammation. Intraperitoneal injections of Ginger-Honey aqueous extract (GHae) before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in the recruitment of eosinophils to the lungs as attested by cell counts in bronchoalveolar lavage (BAL) fluids. Resolution of airway inflammation induced by GHae was accompanied by a suppression of the Th2 cell-driven response to allergen in vivo. Thus, IL-4 and eotaxin levels in the lungs were clearly diminished in ginger-honey-treated mice relative to their controls after allergen sensitization and challenge. Ginger-Honey can suppress Th2-mediated immune responses and might thus provide a possible therapeutic application in inflammation.$$aIn traditional medicine people use the association of ginger and honey to treat some respiratory disorder. The aim of the present study was to examine the effects of the association of ginger and honey on respiratory disorder in mice. Here we showed that ginger-honey can exert such functions in vivo, namely in a mouse model of Th2-mediated pulmonary inflammation. Intraperitoneal injections of Ginger-Honey aqueous extract (GHae) before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in the recruitment of eosinophils to the lungs as attested by cell counts in bronchoalveolar lavage (BAL) fluids. Resolution of airway inflammation induced by GHae was accompanied by a suppression of the Th2 cell-driven response to allergen in vivo. Thus, IL-4 and eotaxin levels in the lungs were clearly diminished in ginger-honey-treated mice relative to their controls after allergen sensitization and challenge. Ginger-Honey can suppress Th2-mediated immune responses and might thus provide a possible therapeutic application in inflammation.
000013139 6531_ $$aGinger$$aGinger$$aAirway Inflammation$$aAirway Inflammation$$aHoney$$aHoney$$aCytokine$$aCytokine
000013139 700__ $$aKONAN, B.A$$aKONAN, B.A$$aAMONKA,K.A$$aAMONKA,K.A$$aZANNOU-TCHOKO, J.V.,$$aZANNOU-TCHOKO, J.V.,$$aKATI COULIBALY, S.$$aKATI COULIBALY, S.
000013139 773__ $$pjpsi$$pjpsi$$tJournal of Pharmaceutical and Scientific Innovations$$tJournal of Pharmaceutical and Scientific Innovations
000013139 8564_ $$uhttps://inveniov1.uvci.edu.ci/record/13139/files/Article%20Ahui%20Marie.pdf$$uhttps://inveniov1.uvci.edu.ci/record/13139/files/Article%20Ahui%20Marie.pdf
000013139 980__ $$aARTICLE$$aARTICLE
000013139 980__ $$aUFHB$$aUFHB
000013139 980__ $$aBV$$aBV